Motif ID: NANOG{mouse}.p2

Z-value: 0.994


Transcription factors associated with NANOG{mouse}.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NANOGchr12_+_79420250.224.2e-01Click!


Activity profile for motif NANOG{mouse}.p2.

activity profile for motif NANOG{mouse}.p2


Sorted Z-values histogram for motif NANOG{mouse}.p2

Sorted Z-values for motif NANOG{mouse}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG{mouse}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_151561094 1.779 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr9_+_112542496 1.574 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr9_+_71819926 1.385 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr10_+_123922940 1.383 TACC2
transforming, acidic coiled-coil containing protein 2
chr12_-_123187842 1.279 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr6_+_148663728 1.244 NM_015278
SASH1
SAM and SH3 domain containing 1
chr10_+_129845806 1.212 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr6_+_31949800 1.189 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr17_+_27370155 1.183 PIPOX
pipecolic acid oxidase
chr12_-_123201319 1.160 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr10_+_123923104 1.127 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr11_+_129939667 1.122 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chr3_-_56809594 1.090 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr3_-_149095517 1.051 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr2_+_64681610 1.036 LGALSL
lectin, galactoside-binding-like
chr14_+_21156922 1.029 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr3_-_149095458 0.951 TM4SF1
transmembrane 4 L six family member 1
chr3_-_149095413 0.926 TM4SF1
transmembrane 4 L six family member 1
chr6_-_2840683 0.914 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr11_+_129939807 0.893 APLP2
amyloid beta (A4) precursor-like protein 2
chr7_+_134576187 0.884 CALD1
caldesmon 1
chr11_+_121461070 0.836 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr11_+_129939792 0.836 APLP2
amyloid beta (A4) precursor-like protein 2
chr20_+_43991739 0.801 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 readthrough
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr2_-_97405775 0.791 LMAN2L
lectin, mannose-binding 2-like
chr3_+_128968470 0.771 COPG
coatomer protein complex, subunit gamma
chr6_-_43423785 0.758 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chr4_+_166248816 0.754 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr4_-_16077740 0.741 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr11_+_129939787 0.726 APLP2
amyloid beta (A4) precursor-like protein 2
chr7_+_144052432 0.686 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr3_+_128968429 0.653 NM_016128
COPG
coatomer protein complex, subunit gamma
chr2_+_219081898 0.629 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr3_+_171757432 0.626 FNDC3B
fibronectin type III domain containing 3B
chr9_+_124030455 0.624 GSN
gelsolin
chr13_-_21099914 0.623 NM_015974
CRYL1
crystallin, lambda 1
chr6_+_148663953 0.619 SASH1
SAM and SH3 domain containing 1
chr10_+_5566923 0.612 NM_005185
CALML3
calmodulin-like 3
chr2_+_102314162 0.606 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr2_+_219081914 0.604 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr22_-_36784001 0.600 MYH9
myosin, heavy chain 9, non-muscle
chr2_+_219081864 0.586 NM_152862
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr9_+_124030413 0.576 GSN
gelsolin
chr9_+_124048396 0.568 GSN
gelsolin
chr2_-_97405799 0.566 NM_001142292
NM_030805
LMAN2L

lectin, mannose-binding 2-like

chr14_-_53417636 0.556 FERMT2
fermitin family member 2
chr22_+_38201232 0.554 H1F0
H1 histone family, member 0
chr12_-_89746238 0.506 DUSP6
dual specificity phosphatase 6
chr3_+_42190736 0.502 TRAK1
trafficking protein, kinesin binding 1
chr12_-_89746244 0.496 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr1_-_43424324 0.489 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr17_+_38375554 0.486 NM_133264
WIPF2
WAS/WASL interacting protein family, member 2
chr14_-_94849552 0.482 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr3_+_31574119 0.474 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr17_+_15848422 0.470 ADORA2B
adenosine A2b receptor
chr16_+_8806825 0.468 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr13_+_58205943 0.467 PCDH17
protocadherin 17
chr13_-_45010994 0.466 TSC22D1
TSC22 domain family, member 1
chr13_-_45010974 0.465 TSC22D1
TSC22 domain family, member 1
chr22_-_36783977 0.464 MYH9
myosin, heavy chain 9, non-muscle
chrX_+_107683015 0.462 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr9_+_124030370 0.453 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr3_-_52567708 0.450 NM_001134231
NT5DC2
5'-nucleotidase domain containing 2
chr2_+_219082119 0.447 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr12_-_110939877 0.441 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr9_-_99382073 0.436 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr1_-_27240430 0.432 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr9_-_116840604 0.430 AMBP
alpha-1-microglobulin/bikunin precursor
chr3_-_121468510 0.426 NM_004487
GOLGB1
golgin B1
chr11_+_129939847 0.423 APLP2
amyloid beta (A4) precursor-like protein 2
chr17_+_7387773 0.422 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr6_-_43021605 0.415 CUL7
cullin 7
chr12_-_85306579 0.407 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr16_+_56703725 0.406 NM_005951
MT1H
metallothionein 1H
chr6_-_32821743 0.401 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr16_+_2587989 0.398 PDPK1
3-phosphoinositide dependent protein kinase-1
chr13_-_48987017 0.396 LPAR6
lysophosphatidic acid receptor 6
chrX_+_106045880 0.386 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr6_-_43021390 0.383 CUL7
cullin 7
chr8_+_28559010 0.383 EXTL3
exostoses (multiple)-like 3
chr19_+_35629727 0.378 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr2_-_85581563 0.378 NM_017750
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr2_-_183902747 0.375 NCKAP1
NCK-associated protein 1
chr18_+_55816546 0.372 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr13_-_45010937 0.372 TSC22D1
TSC22 domain family, member 1
chr2_+_64751545 0.370 AFTPH
aftiphilin
chr3_-_52567809 0.370 NT5DC2
5'-nucleotidase domain containing 2
chr3_-_139258373 0.368 RBP1
retinol binding protein 1, cellular
chr3_-_139258477 0.367 RBP1
retinol binding protein 1, cellular
chr1_-_154193044 0.363 C1orf43
chromosome 1 open reading frame 43
chr22_+_45148437 0.363 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr6_-_43484701 0.360 NM_015388
YIPF3
Yip1 domain family, member 3
chr3_+_46619075 0.343 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr8_-_17580024 0.341 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr16_+_2588000 0.330 PDPK1
3-phosphoinositide dependent protein kinase-1
chr10_-_79686279 0.324 NM_004747
DLG5
discs, large homolog 5 (Drosophila)
chr10_+_102792166 0.323 SFXN3
sideroflexin 3
chr1_-_86043932 0.318 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_-_188312872 0.318 NM_005795
CALCRL
calcitonin receptor-like
chr2_+_113875469 0.315 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chrX_+_54834107 0.315 NM_177433
MAGED2
melanoma antigen family D, 2
chr10_+_102792161 0.315 SFXN3
sideroflexin 3
chr13_-_48987247 0.314 LPAR6
lysophosphatidic acid receptor 6
chr4_-_16900256 0.311 LDB2
LIM domain binding 2
chr19_+_15218141 0.309 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr12_-_53012332 0.306 NM_175068
KRT73
keratin 73
chr17_+_7387688 0.306 NM_000937
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr14_-_60632058 0.303 NM_016029
DHRS7
dehydrogenase/reductase (SDR family) member 7
chr10_-_101690655 0.302 DNMBP
dynamin binding protein
chr3_-_50360109 0.300 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr10_+_124220990 0.298 NM_002775
HTRA1
HtrA serine peptidase 1
chr19_-_50370799 0.293 NM_007254
PNKP
polynucleotide kinase 3'-phosphatase
chr12_-_58160823 0.289 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr9_-_116840545 0.289 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_+_19551835 0.288 NM_000382
NM_001031806
ALDH3A2

aldehyde dehydrogenase 3 family, member A2

chr22_+_21128378 0.287 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr16_+_2588051 0.287 PDPK1
3-phosphoinositide dependent protein kinase-1
chr22_+_38142255 0.286 TRIOBP
TRIO and F-actin binding protein
chr9_+_116356199 0.284 NM_144489
RGS3
regulator of G-protein signaling 3
chr9_-_116840460 0.283 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_+_64133915 0.282 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr14_-_94856926 0.282 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr19_-_54327428 0.279 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr2_+_62900985 0.276 NM_001142615
EHBP1
EH domain binding protein 1
chr8_+_9413390 0.276 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr1_-_147245483 0.273 NM_005266
GJA5
gap junction protein, alpha 5, 40kDa
chr3_+_15469052 0.269 NM_033083
EAF1
ELL associated factor 1
chr19_-_10764449 0.267 LOC147727
uncharacterized LOC147727
chr4_-_122618140 0.266 NM_001154
ANXA5
annexin A5
chr6_+_292456 0.266 DUSP22
dual specificity phosphatase 22
chr11_+_69455938 0.265 CCND1
cyclin D1
chr8_+_28559143 0.264 NM_001440
EXTL3
exostoses (multiple)-like 3
chr14_+_95027760 0.262 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr4_-_122618129 0.262 ANXA5
annexin A5
chr7_-_99277518 0.262 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chrX_+_23801431 0.255 SAT1
spermidine/spermine N1-acetyltransferase 1
chr8_-_19540093 0.251 NM_018371
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr10_-_116418056 0.251 NM_002313
ABLIM1
actin binding LIM protein 1
chr9_-_116840673 0.250 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr6_-_43021630 0.248 NM_001168370
NM_014780
CUL7

cullin 7

chr8_-_17579729 0.248 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr3_+_31574431 0.244 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr16_+_8768403 0.239 NM_020686
ABAT
4-aminobutyrate aminotransferase
chrX_+_54834775 0.236 NM_014599
MAGED2
melanoma antigen family D, 2
chr17_+_1646290 0.235 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr11_-_72504643 0.233 NM_006645
STARD10
StAR-related lipid transfer (START) domain containing 10
chr22_-_39636906 0.233 NM_033016
PDGFB
platelet-derived growth factor beta polypeptide
chr11_+_69455837 0.231 NM_053056
CCND1
cyclin D1
chr20_-_56284945 0.231 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr2_-_24307529 0.229 NM_004881
NM_147184
TP53I3

tumor protein p53 inducible protein 3

chr3_-_151034514 0.227 NM_023915
GPR87
G protein-coupled receptor 87
chr20_-_61557818 0.227 DIDO1
death inducer-obliterator 1
chr19_+_35531409 0.223 NM_002151
NM_182983
HPN

hepsin

chr18_+_21452981 0.222 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr17_-_7197811 0.220 YBX2
Y box binding protein 2
chr6_-_46889620 0.218 NM_001098518
GPR116
G protein-coupled receptor 116
chr3_-_15468981 0.216 NM_152396
METTL6
methyltransferase like 6
chrX_-_41782230 0.211 NM_001126054
NM_001126055
NM_003688
CASK


calcium/calmodulin-dependent serine protein kinase (MAGUK family)


chr22_-_36783851 0.211 MYH9
myosin, heavy chain 9, non-muscle
chr6_+_90272036 0.210 NM_001242811
ANKRD6
ankyrin repeat domain 6
chr6_+_114178516 0.210 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chrX_-_107682600 0.208 NM_001847
COL4A6
collagen, type IV, alpha 6
chr6_-_99873129 0.203 NM_015491
NM_032870
PNISR

PNN-interacting serine/arginine-rich protein

chr4_+_154125589 0.202 NM_015271
TRIM2
tripartite motif containing 2
chr12_+_53442732 0.202 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr8_+_22132809 0.202 NM_018068
PIWIL2
piwi-like 2 (Drosophila)
chr16_+_69680959 0.201 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr17_-_7197896 0.201 YBX2
Y box binding protein 2
chr10_-_1034280 0.201 LOC100288619
uncharacterized LOC100288619
chr2_+_102508377 0.197 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr20_+_35973083 0.195 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr8_+_31497267 0.194 NM_013962
NRG1
neuregulin 1
chr17_-_7197866 0.193 NM_015982
YBX2
Y box binding protein 2
chr14_-_23058062 0.192 DAD1
defender against cell death 1
chr3_-_57113292 0.189 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr22_-_36784055 0.187 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr22_-_51021337 0.185 NM_005198
CHKB
CHKB-CPT1B
choline kinase beta
CHKB-CPT1B readthrough (non-protein coding)
chr16_+_3507956 0.184 NM_001083600
NM_024845
NAA60

N(alpha)-acetyltransferase 60, NatF catalytic subunit

chr11_-_6341708 0.183 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr17_-_38073792 0.183 NM_018530
GSDMB
gasdermin B
chrX_-_48828250 0.181 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr7_-_86974693 0.181 TP53TG1
TP53 target 1 (non-protein coding)
chr16_+_640091 0.180 RAB40C
RAB40C, member RAS oncogene family
chr4_-_16900028 0.180 LDB2
LIM domain binding 2
chr6_+_99872769 0.179


chr17_-_39780762 0.178 NM_000422
KRT17
keratin 17
chr20_-_61557842 0.177 DIDO1
death inducer-obliterator 1
chr17_-_34313685 0.177 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chr10_+_99258615 0.176 NM_024954
UBTD1
ubiquitin domain containing 1
chr16_-_31147062 0.175 NM_002773
PRSS8
protease, serine, 8
chr17_-_77005741 0.174 CANT1
calcium activated nucleotidase 1
chr11_+_69455978 0.173 CCND1
cyclin D1
chr5_+_50679239 0.172 ISL1
ISL LIM homeobox 1
chr17_-_7518124 0.170 NM_004860
FXR2
fragile X mental retardation, autosomal homolog 2
chrX_+_38420690 0.169 NM_004615
TSPAN7
tetraspanin 7
chr9_+_137218313 0.169 NM_002957
RXRA
retinoid X receptor, alpha
chr8_-_70983549 0.169 NM_024504
PRDM14
PR domain containing 14
chr2_+_68961912 0.168 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr2_-_136873740 0.168 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr7_+_116312412 0.168 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
281.13 3.80e-04 GO:0004522 pancreatic ribonuclease activity
187.44 9.11e-04 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
129.79 1.97e-03 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
22.45 5.29e-03 GO:0004866 endopeptidase inhibitor activity
22.06 5.58e-03 GO:0030414 peptidase inhibitor activity
21.50 6.01e-03 GO:0061135 endopeptidase regulator activity
17.76 1.06e-02 GO:0061134 peptidase regulator activity
52.77 1.24e-02 GO:0004521 endoribonuclease activity
34.48 2.90e-02 GO:0004540 ribonuclease activity
11.46 3.79e-02 GO:0004857 enzyme inhibitor activity